Clinically Proven, Doctor-Recommended Science sets Medifast and your weight loss success apart from the rest.

Medifast is not a pill or a quick fix; it’s a plan that works. And because it does, Medifast is the brand recommended by over 20,000 doctors since 1980.

Medifast has a long, clinical heritage of facilitating the weight loss success stories for thousands of customers and patients. It’s through our unique meal plans that we provide you with formulated nutrition and lifelong habits for weight management.

Our story began with Dr. William Vitale. His specially formulated meal plan proved successful for his patients that, many times, needed to lose life-saving weight. His mission was that they do so healthily and with long-term results. His patients’ success can now be yours.

So why have I never heard about Medifast?

Medifast has lived in the clinical setting for many years. It’s only been within the past decade that Medifast was formulated to be available to you without a doctor’s supervision. Medifast is safe and effective to do on your own whether you want to lose 15 or 120 or more pounds.

Medifast Nutrition and How It Works to Make You Lose Weight

Medifast weight loss meal are nutrient dense and fortified with 24 vitamins and minerals, so you can lose pounds and inches without losing out on nutrition. Each meal has essentially the same nutritional profile, and has been designed to have enough low-fat protein and healthy fiber to keep you full and satisfied, without the between-meal hunger that can sabotage a weight loss plan.

The Key?

After a few days on the Medifast Weight Loss Plan, your body will reach a mild fat-burning state, so you can lose quickly while preserving muscle tissue. It’s while maintaining that fat-burning state that you will continue to lose weight when on the plan.

Scientific Advisors to Ensure Continued Effectiveness

Medifast employs a Scientific Advisory Board that’s composed of a distinguished panel of scientists and doctors. Their role is to review the effectiveness, safety, and nutritional benefits of Medifast’s products and programs. The board also helps develop new meals and supplements and investigates alternate weight-loss approaches for those with special medical or nutritional needs, such as patients with heart disease or those who follow a vegetarian diet. We have options for just about anyone.

Commitment to Science and Nutrition

Clinical studies prove time and again that Medifast works.

  • Clinically proven safe and effective by researchers as major university teaching hospitals.
  • Studies published in major medical journals have proven meal replacements to be an effective method of weight loss and weight maintenance.


Clinical studies prove time and again that Medifast works. Read the research here.*

Study 1

Nutrition Journal. Davis, et al.

This study compared the Medifast Program to a conventional USDA food-based diet of equal calories. After 16 weeks of weight loss, the results suggested that the Medifast program is a more effective strategy for producing robust initial weight loss and for achieving improvements in a number of health-related parameters during weight maintenance.

Study 2

Diabetes Educator. Cheskin, et al.

Overweight and obese individuals diagnosed with type 2 diabetes were split into two groups: Those using Medifast Meals lost almost twice as much weight, experienced less weight regain after one year and were more likely to complete the program compared to those on the standard diet.

Study 3

Eating Weight Disorders. Haddock, et al.

To evaluate the long-term impact of Medifast Meals combined with the use of appetite suppression medications, charts from a medically-supervised weight loss clinic were reviewed. Results showed this combination of Medifast Meals and appetite suppression medications produced significant and sustained weight loss and were better than those typically reported for weight loss drugs alone.

Study 4

The Open Nutrition Journal. Davis, et al.

The ingredients of Medifast's CalorieBurn products (containing caffeine and EGCG) were evaluated for their effects on metabolism, fat oxidation, and appetite. Study results showed an increase in resting energy expenditure, a trend for increased fat oxidation and a reduction in appetite after consumption.

New publications

C. Coleman, J. Kiel, A. Hanlon-Mitola, C. Sonzone, N. Fuller and L. Davis, "Use of the Medifast Meal Replacement Program for Weight Loss in Overweight and Obese Clients: A Retrospective Chart Review of Three Medifast Weight Control Centers (MWCC)," Food and Nutrition Sciences, Vol. 3 No. 10, 2012, pp. 1433-1444. doi: 10.4236/fns.2012.310187.

MWCC Retrospective Chart Review. Food and Nutrition Sciences. Coleman, et al.

A chart review was performed to evaluate the effectiveness of the 5 & 1 Plan in the Medifast Weight Control Centers. Results showed robust weight and health-related results were achieved with adherence to the Medifast Program recommendations and attendance at weekly one-on-one support sessions.

View Study (PDF) >

* All studies based on the heritage Medifast 5 & 1 Plan.

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Medifast, Inc., Health & Wellness, Owings Mills, MD HACKER SAFE certified sites prevent over 99.9% of hacker crime.Medifast makes no claim that these results are representative of all participants on the Medifast Program. Medifast recommends you consult with a physician before starting a weight-loss program. Medifast is the brand recommended by more than 20,000 doctors since 1980.

Davis, L.M., Coleman, C.D., Kiel, J., Rampolla, J., Hutchisen, T., Ford, L., Andersen, W.S., Hanlon-Mitola, A. (2010). Efficacy of a meal replacement diet compared to a food-based diet after a period of weight loss and weight maintenance: a randomized controlled trial. Nutrition Journal, 9(11). View Study